Das Institut für Klinische Pharmakologie und Toxikologie begrüßt Sie

Portrait Prof. Dr. Reinhold Kreutz

Prof. Dr. Reinhold Kreutz

Auf unseren Seiten finden Sie Informationen zu:



im Bereich der Arzneimitteltherapie,

Forschung und

aktuellen Themen

Aktuelle Publikationen

Frombach J, Sonnenburg A, Krapohl BD, Zuberbier T, Peiser M, Stahlmann R, Schreiner M
Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly.
Arch Toxicol 2018; Jan 30. doi: 10.1007/s00204-018-2164-5. [Epub ahead of print]
Beyer-Westendorf J, Kreutz R, Posch F, Ay C
The CHA(2)DS(2)-VASc score strongly correlates with glomerular filtration rate and predicts renal function decline over time in elderly patients with atrial fibrillation and chronic kidney disease.
Int J Cardiol 2018; Feb 15;253:71-77. doi: 10.1016/j.ijcard.2017.10.110.
Volpe M, Tocci G, de la Sierra A, Kreutz R, Laurent S, Manolis AJ, Tsioufis K
Personalised Single-Pill Combination Therapy in Hypertensive Patients: An Update of a Practical Treatment Platform.
High Blood Press Cardiovasc Prev 2017; Dec;24(4):463-472. doi: 10.1007/s40292-017-0239-7. Epub 2017 Oct 31.
Rehm J, Anderson P, Prieto JAA, Armstrong I, Aubin HJ, Bachmann M, Bastus NB, Brotons C, Burton R, Cardoso M, Colom J, Duprez D, Gmel G, Gual A, Kraus L, Kreutz R, Liira H, Manthey J, Møller L, Okruhlica Ľ, Roerecke M, Scafato E, Schulte B, Segura-Garcia L, Shield KD, Sierra C, Vyshinskiy K, Wojnar M, Zarco J
Towards new recommendations to reduce the burden of alcohol-induced hypertension in the European Union..
BMC Med 2017; Sep 28;15(1):173. doi: 10.1186/s12916-017-0934-1.
Douros A, Yin H, Yu OHY, Filion KB, Azoulay L, Suissa S
Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events.
Diabetes Care 2017; Nov;40(11):1506-1513. doi: 10.2337/dc17-0595. Epub 2017 Sep 1.
Douros A, Bronder E, Klimpel A, Erley C, Garbe E, Kreutz R
Drug-induced kidney injury: A large case series from the Berlin Case-Control Surveillance Study.
Clin Nephrol 2018; Jan;89 (2018)(1):18-26. doi: 10.5414/CN109212.
Degen GH, Ali N, Gundert-Remy U
Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers.
Toxicol Lett 2018; Jan 5;282:43-48. doi: 10.1016/j.toxlet.2017.10.006. Epub 2017 Oct 10.
Hoeltzenbein M, Beck E, Fietz AK, Wernicke J, Zinke S, Kayser A, Padberg S, Weber-Schoendorfer C, Meister R, Schaefer C
Pregnancy Outcome After First Trimester Use of Methyldopa: A Prospective Cohort Study.
Hypertension 2017; Jul;70(1):201-208. doi: 10.1161/HYPERTENSIONAHA.117.09110. Epub 2017 May 22.
Douros A, Renoux C, Coulombe J, Suissa S
Patterns of long-term use of non-vitamin K antagonist oral anticoagulants for non-valvular atrial fibrillation: Quebec observational study.
Pharmacoepidemiol Drug Saf 2017; Dec;26(12):1546-1554. doi: 10.1002/pds.4333. Epub 2017 Oct 6.
Kreutz R, Scholze J, Douros A
Single-Pill Triple Fixed Dose Combination Therapy with Single Component Drug Monitoring in Treatment-Resistant Hypertension: A Pilot Study.
Curr Vasc Pharmacol 2018; Jan 26;16(2):197-203. doi: 10.2174/1570161115666170821155555.
Kreutz R, Persson PB, Kubitza D, Thelen K, Heitmeier S, Schwers S, Becka M, Hemmrich M
Dissociation between the pharmacokinetics and pharmacodynamics of once-daily rivaroxaban and twice-daily apixaban: a randomized crossover study.
J Thromb Haemost 2017; Oct;15(10):2017-2028. doi: 10.1111/jth.13801. Epub 2017 Sep 14.
Wadelius M, Eriksson N, Kreutz R, Bondon-Guitton E, Ibañez L, Carvajal A, Lucena MI, Sancho Ponce E, Molokhia M, Martin J, Axelsson T, Kohnke H, Yue QY, Magnusson PKE, Bengtsson M, Hallberg P; EuDAC
Sulfasalazine-induced agranulocytosis is associated with the human leukocyte antigen locus.
Clin Pharmacol Ther 2017; Aug 1. doi: 10.1002/cpt.805. [Epub ahead of print]
Pleyer U, Algharably EA, Feist E, Kreutz R
Small molecules as therapy for uveitis: a selected perspective of new and developing agents.
Expert Opin Pharmacother 2017; Sep;18(13):1311-1323. doi: 10.1080/14656566.2017.1361408. Epub 2017 Aug 7.
Schaberg T, Bauer T, Brinkmann F, Diel R, Feiterna-Sperling C, Haas W, Hartmann P, Hauer B, Heyckendorf J, Lange C, Nienhaus A, Otto-Knapp R, Priwitzer M, Richter E, Rumetshofer R, Schenkel K, Schoch OD, Schönfeld N, Stahlmann R
[Tuberculosis Guideline for Adults - Guideline for Diagnosis and Treatment of Tuberculosis including LTBI Testing and Treatment of the German Central Committee (DZK) and the German Respiratory Society (DGP).
Pneumologie 2017; 71(6):325-397. doi: 10.1055/s-0043-105954. Epub 2017 Jun 26. German.
Algharably EAH, Bolbrinker J, Lezius S, Reibis R, Wegscheider K, Völler H, Kreutz R
Uromodulin associates with cardiorenal function in patients with hypertension and cardiovascular disease.
J Hypertens 2017; Oct;35(10):2053-2058. doi: 10.1097/HJH.0000000000001432.
Leppert U, Gillespie A, Orphal M, Böhme K, Plum C, Nagorsen K, Berkholz J, Kreutz R, Eisenreich A
The impact of α-Lipoic acid on cell viability and expression of nephrin and ZNF580 in normal human podocytes.
Eur J Pharmacol 2017; Sep 5;810:1-8. doi: 10.1016/j.ejphar.2017.06.013. Epub 2017 Jun 10.
Degen GH, Partosch F, Muñoz K, Gundert-Remy U
Daily uptake of mycotoxins - TDI might not be protective for nursed infants.
Toxicol Lett 2017; Jun 7;277:69-75. doi: 10.1016/j.toxlet.2017.06.002. [Epub ahead of print].
Bolbrinker J, Garbe E, Douros A, Huber M, Bronder E, Klimpel A, Andersohn F, Meyer O, Salama A, Kreutz R
Immobilization and high platelet count are associated with thromboembolic complications in heparin-induced thrombocytopenia.
Pharmacoepidemiol Drug Saf 2017; Oct;26(10):1149-1155. doi: 10.1002/pds.4235. Epub 2017 May 24.
Bolbrinker J, Zaidi Touis L, Gohlke H, Weisser B, Kreutz R
European guidelines on lifestyle changes for management of hypertension : Awareness and implementation of recommendations among German and European physicians.
Herz 2017; May 22. doi: 10.1007/s00059-017-4575-0. [Epub ahead of print]
Abdel-Hady Algharably E, Beige J, Kreutz R, Bolbrinker J
Effect of UMOD genotype on long-term graft survival after kidney transplantation in patients treated with cyclosporine-based therapy.
Pharmacogenomics 2017; Apr 18. doi: 10.1038/tpj.2017.14. [Epub ahead of print]
Turpie AGG, Mantovani LG, Haas S, Kreutz R, Monje D, Schneider J, van Eickels M, Gebel M, Ageno W
Analysis of patients with deep vein thrombosis switched from standard therapy to rivaroxaban in the non-interventional XALIA study.
Thromb Res 2017; Apr 13;155:23-27. doi: 10.1016/j.thromres.2017.04.001. Epub 2017 Apr 13.
Rekers NV, Flaig TM, Mallat MJ, Spruyt-Gerritse MJ, Zandbergen M, Anholts JD, Bajema IM, Clahsen-van Groningen MC, Yang J, de Fijter JW, Claas FH, Brakemeier S, Lachmann N, Kreutz R, de Heer E, Budde K, Bolbrinker J, Eikmans M
Donor genotype and intragraft expression of CYP3A5 reflect the response to steroid treatment during acute renal allograft rejection.
Transplantation 2016; Sep;101(9):2017-2025. doi: 10.1097/TP.0000000000001584.
Dräger D, Budnick A, Kuhnert R, Kalinowski S, Könner F, Kreutz R
Pain management intervention targeting nursing staff and general practitioners: Pain intensity, consequences and clinical relevance for nursing home residents.
Geriatr Gerontol Int 2017; Oct;17(10):1534-1543. doi: 10.1111/ggi.12924. Epub 2016 Dec 9.
Langer S, Kreutz R, Eisenreich A
Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions.
J Nephrol 2016; Dec;29(6):765-773. Epub 2016 Jan 5.
Mielke H, Di Consiglio E, Kreutz R, Partosch F, Testai E, Gundert-Remy U
The importance of protein binding for the in vitro-in vivo extrapolation (IVIVE)-example of ibuprofen, a highly protein-bound substance.
Arch Toxicol 2017; Apr;91(4):1663-1670. doi: 10.1007/s00204-016-1863-z. Epub 2016 Oct 21.
Algharably EA, Filler I, Rosenfeld S, Grabowski K, Kreutz R
Statin intolerance - a question of definition.
Expert Opin Drug Saf 2017; Jan;16(1):55-63. Epub 2016 Sep 27.
Frombach J, Sonnenburg A, Krapohl BD, Zuberbier T, Stahlmann R, Schreiner M
A novel method to generate monocyte-derived dendritic cells during coculture with HaCaT facilitates detection of weak contact allergens in cosmetics.
Arch Toxicol 2017; Jan;91(1):339-350. doi: 10.1007/s00204-016-1722-y. Erratum in PMID: 27344342.
Flaig T, Douros A, Bronder E, Klimpel A, Kreutz R, Garbe E
Tocilizumab-induced pancreatitis: case report and review of data from the FDA Adverse Event Reporting System.
J Clin Pharm Ther 2016; Dec;41(6):718-721. doi: 10.1111/jcpt.12456. Epub 2016 Sep 27.
Flaig TM, Budnick A, Kuhnert R, Kreutz R, Dräger D
Physician Contacts and Their Influence on the Appropriateness of Pain Medication in Nursing Home Residents: A Cross-Sectional Study.
Am Med Dir Assoc 2016; Sep 1;17(9):834-8. doi: 10.1016/j.jamda.2016.05.014. Epub 2016 Jun 24.
Weidner C, Steinfath M, Opitz E, Oelgeschläger M, Schönfelder G
Defining the optimal animal model for translational research using gene set enrichment analysis.
EMBO Mol Med 2016; Aug 1;8(8):831-8. doi: 10.15252/emmm.201506025.

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Heike Negatu

Heike Negatu

CharitéUniversitätsmedizin Berlin

CCM: Campus Charité Mitte

CharitéCentrum Diagnostische und präventive Labormedizin CC 5

Institut für Klinische Pharmakologie und Toxikologie


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